Background: Prostate cancer is one of the most prevalent cancers affecting men globally, with increasing incidence in India. Early detection and awareness of risk factors, preventive measures, and treatment options significantly improve outcomes. In rural and semi-urban areas such as Himachal Pradesh, awareness of prostate cancer remains low, with limited access to diagnostic and educational resources. Understanding the knowledge gaps among the population is crucial for developing effective public health strategies.Materials and Methods: A descriptive, cross-sectional study was conducted among 412 individuals in Himachal Pradesh using a structured questionnaire. The questionnaire assessed socio-demographic details and knowledge of prostate cancer, including its risk factors, symptoms, diagnostic methods, and treatment options. Participants were categorized into four knowledge levels based on their responses: very good (>80%), good (60–79%), fair (41–59%), and poor (<40%). Data were analyzed using descriptive statistics and chi-square tests to explore correlations between socio-demographic variables and knowledge scores.Results: Of the 412 participants, 59.3% were male, and 40.7% were female. Rural residents comprised 60.5% of the sample, with 38.5% falling into the middle-income category (INR 10,001–20,000 monthly). While 73.5% recognized men over 50 as a high-risk group, awareness of lifestyle-related risk factors such as smoking (49.3%) and physical inactivity (59.5%) was moderate. Knowledge of early detection methods, including PSA testing, was reported by 61.8%, and 65.3% were aware of treatment options like radiation therapy. Knowledge scores revealed that 59.8% of participants had good to very good awareness, while 40.2% fell into fair or poor categories.Conclusion: The study highlights a foundational awareness of prostate cancer among the general public in Himachal Pradesh but identifies critical gaps in technical knowledge and preventive practices. Targeted community-based education initiatives, integrating culturally appropriate and accessible materials, are essential to bridge these gaps. Public health strategies focusing on rural and underserved populations can promote early detection, healthier lifestyles, and better prostate cancer outcomes.