Background: Osteoarthritis (OA) is the most common disease of the joints worldwide, with the knee being the most commonly affected joint in the body This study was undertaken with the objective to assess the knowledge about risk and preventive factors for osteoarthritis Knee among Ortho OPD patients in civil hospital Rohru. Materials and Methods: This cross-sectional study was conducted between Aug- December 2020 among Ortho OPD patients in civil hospital Rohru selected by convenience Sampling Technique. Information regarding their socio-demographic characteristics and knowledge, regarding risk and preventive factors for osteoarthritis Knee were obtained using a self-administered, pre-tested, semi-structured questionnaire. Data was analyzed using Epi info v7 software using appropriate statistical tests. Results: In the present stud, 35% (140) of the Patients fall were below 40 years of age while 65% (260) were above 40 years. 54% (216) of patients were male and 46% (184) were female. Among the total patients. Among the total patients, 56(14.0%%) didn’t know about any risk factor of osteoarthritis Knee. 302 (75.5%)     respondents said that Inadequate amounts of dietary calcium & vitamin D is the risk factor of osteoarthritis Knee, followed by Bad posture and poor gait by 156(39%). Among the total patients, maximum 345(86.25 %) told that Calcium and Vitamin D supplements helps in Prevention of osteoarthritis Knee, followed by calcium-rich foods 216(54%).62 (15.5%) respondents didn’t know about any preventive factor of osteoarthritis Knee. Conclusion: Still many respondents didn’t know about the risk as well as preventive factors of Osteoarthritis knee. Calcium and Vitamin D supplements Knee, calcium-rich foods, good posture and gait, Greece capsule(glucosamine), Exercise & yoga, Knee cap / bracing, Maintenance of ideal weight, Prevention of injury to knee joint and healthily balanced diet helps in Prevention of osteoarthritis Knees.