Keratosis pilaris could be a common, life-long skin condition that influences roughly 40% of grown-ups and 50-80% of young people. This condition is more broad in females than in guys [1]. Keratosis pilaris frequently gets to be more overstated at adolescence but tends to gotten to be less articulated with expanding age. Seasonal variety is now and then famous, as within the winter, dry skin gets to be more predominant and can decline the condition for a few patients. In a few cases, the clutter can be cosmetically distorting and mentally discomforting.

Keratosis pilaris shows up as unpleasant folliculocentric keratotic papules that regularly happen on the upper arms and thighs; be that as it may, other areas have moreover been detailed. It could be a hereditary clutter of keratinization of the hair follicles, with around 30-50% of patients having a family history [1]. The illness is most regularly caused by a buildup of keratin, and within the larger part of patients, the method of keratinization is accepted to be imperfect. An abundance of skin cells builds up near to person hair follicles, and the person papules are a result of the hair being caught beneath the abundance skin cells and flotsam and jetsam, as they are not able to reach the surface [2]. Regularly, coiled hair may be visualized beneath the papule.

A well-known treatment for keratosis pilaris is the utilize of laser treatment. Amid laser treatment sessions, the skin is subjected to shinning lights. These shinning lights enter the skin and specifically target the melanin within the hair follicle [3]. The melanin retains the vitality and devastates the hair follicle [3]. In any case, lase  medications are regularly costly and are not simple for the normal individual to get to, in expansion to advance issues that may result such as swelling and rankles [3]. This account survey examines other strategies that have been utilized to treat keratosis pilaris that seem demonstrate to be more useful. 

This paper points to investigate the impacts steroids, on keratosis pilaris. A writing look of articles distributed between 1955 and 2021 utilizing PubMed was performed utilizing the catchphrases “keratosis pilaris,” and “steroid.” Articles that included newborn children, the elderly, sensitivities related to steroids, existing history of skin surgeries, and skin injury were prohibited. Titles and abstracts were analyzed to guarantee patients were not in a compromised state some time recently the treatment of keratosis pilaris. This audit included case considers and bunch ponders. The articles were analyzed for the sort of treatment utilized for keratosis pilaris, the measurement or concentration of the treatment strategy, and the in general comes about on keratosis pilaris. Comes about from the considers were analyzed in a mixed-methodology way utilizing both quantitative and subjective examination to make an all-encompassing survey. The quantitative examination included rates of adequacy in a few of the medicines, such as how numerous patients famous enhancements in their condition. The subjective examination included portrayals of visual components of keratosis pilaris, such as the examination of the appearance of the keratotic papules. A add up to of 49 articles were distinguished, of which 6 were at long last surveyed (Diagram 1). As it were articles that were accessible online and in English were included in this survey

Diagram 1: Journals Analysis Flow Chart

Steroids are among a few of the compounds that influence keratosis pilaris. Topical and systemic steroids offer assistance by diminishing aggravation, working straightforwardly against skin break out disarranges [4]. Concurring to the ponders consolidated in this audit, particular cases of steroids that impact skin break out conditions incorporate triamcinolone, hydrocortisone, mometasone furoate, testosterone, prednisone, methylprednisolone, and clobetasol propionate.

Whereas steroids influence keratosis pilaris, the sorts change, at the side their concentrations and doses. A concentra­tion that's too low would not essentially bring around the benefits that steroid is assumed to make for the skin. Be that as it may, in case the concentration of steroid is as well tall, there's an expanded plausibility of provocative skin conditions. This will especially influence patients who have a delicate skin sort. The concentration of steroid too depends on the sort of steroid that's utilized.

Measurements of steroids are vital to examine for drugs as as well much or as well small can create undesirable side impacts. For occasion, testosterone is managed at 1.1-8 nmol [5]. Concurring to the considers included in this survey, hydrocortisone is managed at 2.5%, triamcinolone at 0.1%, mometasone furoate at 0.1%, and clobetasol propionate at 0.05% [6,7].Prednisone and methylprednisolone are managed at 20 mg per day and 6 mg per day, separately [8,9]

Table 1: Summary of Summary of Research Effects of Steroid Use on Keratosis Pilaris

Steroids have too appeared empowering comes about when treating skin break out. The utilize of hydrocortisone demonstrated to decrease erythema [6]. Hydrocortisone, coupled with triamcinolone, mometasone furoate, and clobetasol propionate, had a positive impact in a think about as injuries appeared critical change when patients followed to maintaining a strategic distance from warm [7]. Prednisone caused slow vanishing of lichenoid papules, progressing the appearance of keratosis pilaris [8]. Be that as it may, a few corticosteroids really cause more hurt to the patients. In one think about, methylprednisolone delivered a huge number of yellow papules on the confront and hyperproliferation of sebaceous organs [9]. The expansion of the sebaceous organs demonstrated that it would not be the most excellent treatment for keratosis pilaris because it would likely result in an expanded predominance of hair follicles. In another clinical ponder, it was concluded that regulating testosterone relates with expanded seriousness of keratosis pilaris [5]

The capacity of particular steroids that can decrease the seriousness of the condition appears to be the root of planned medications of keratosis pilaris. Assist thinks about ough to be conducted with diverse sorts of steroids to get it their long-term impacts on moderating the dull bumps of keratosis pilaris. These considers ought to be given more need by dermatologists and healthcare pioneers as a practical and commonsense treatment for keratosis pilaris, as well as other clutters closely related to keratosis pilaris.

The authors declare that they have no conflict of intere

No funding sources

The study was approved by the Brawijaya University, Indonesia.

1. Alai, A. N. (2014). Keratosis pilaris: diagnosis and treatment. https://www.aad.org/public/diseases/a-z/keratosis-pilaris-treatment

2. Hwang, S., & Schwartz, R. A. (2008). Keratosis pilaris: a common follicular hyperkeratosis. Cutis, 82(3), 177-180. https://pubmed.ncbi.nlm.nih.gov/18856156/ 

3. Mayo Clinic. (2021). Laser hair removal. Mayo Foundation for Medical Education and Research. (2022, Jul 26. https://www.mayoclinic.org/tests-procedures/laser-hair-removal/about/pac-20394555 2020

4. Tay, Y. K., Kong, K. H., Khoo, L., Goh, C. L., & Giam, Y. C. (2002). The prevalence and descriptive epidemiology of atopic dermatitis in Singapore school children. British Journal of Dermatology, 146(1), 101-106.

5. EARTH, J., Ng, L. L., Wojnarowska, F., & Dawber, R. P. R. (1988). Acanthosis nigricans, insulin resistance and cutaneous virilism. British Journal of Dermatology, 118(5), 613-619.

6. Edelstein, A. J. (1955). Treatment for ulerythema ophryogenes with hydrocortisone ointment. AMA Archives of Dermatology, 71(4), 450.

7. Jeffries, M. L., Aleck, K. A., Bernert, R. A., & Hansen, R. C. (2010). Eccrine squamous metaplasia and periadnexal granulomas: new cutaneous histopathologic findings in cardiofaciocutaneous syndrome. Pediatric dermatology, 27(3), 274-278.

8. Zegarska, B., Kallas, D., Schwartz, R. A., Czajkowski, R., Uchanska, G., & Placek, W. (2010). Graham-Little syndrome. Acta Dermatovenerologica Alpina, Pannonica, et Adriatica, 19(3), 39-42.

9. Caytemel, C., Demir, F. T., Uzuner, E. G., & Turkoglu, Z. (2020). Systemic isotretinoin treatment in a renal transplant patient developing sebaceous hyperplasia due to cyclosporine. Northern Clinics of İstanbul, 7(6), 628.