Background: the changes in blood parameters are linked with inflammation and vascular disorders. Changes included several hematological parameters, including the size, morphology, and normal physiological roles of red blood cells(RBCs), white blood cells(WBCs), and platelets, can be linked to hyperglycemia and accompanying metabolic syndrome. Therefore, the current study is designed to assess the blood indices, especially platelet indices, in type 2 diabetes mellitus patients.Material and methods: This research included 60 patients with diabetes mellitus type II of only Iraqi’s males and females with age of (56.86 ± 1.65) years and (20) samples of apparently healthy Iraqi volunteers with mean age (51.00 ± 4.35) years, who has no history of diabetes and blood diseases with normal blood tests, all the samples was collected from the private laboratory of AL-Iraq laboratory in Diyala province from patients who intended the Lab for routine checkup.  The desired tests (random blood sugar and complete blood count (CBC) were performed on each sample. the results were obtained from the Lab management. Results: The results showed a significant increase of WBC, MPV, and RDW-CV in patients group when compared with control group, while significant decrease level of MCHC was shown in patient group in compare with control. However, the other parameters showed no significant changes between study groups. Conclusion: In conclusion it has been found that type II diabetes mellitus has an effect on the blood parameters that reflects the inflammatory state of hyperglycemia leading to complications as cardiovascular diseases.