Suicide is a major public health concern all over China, and it is one of the top causes of mortality among American young people. There have been significant shifts in teenage suicide, particularly among young females, with the recent uptick in the suicide rate in the United States. That's why it's crucial that they have a firm grasp on the many circumstances that might lead young people to attempt suicide. The clinical and psychological risk factors for suicidal conduct may be predicted to assist identify treatment choices and have empirical value if they were linked to the underlying neurobiological and cognitive abnormalities associated with suicidal behaviour. Their model of possible explanation proposes that changes in suicidal behaviour may have causal importance across several levels of explanation, including developmental, biological (genomics, proteome, epigenetics, immunological), and psychological/clinical. Therefore, their model offers a unified hypothesis to better comprehend this multifaceted finding by bringing together findings from various areas of research on suicidality and making an effort to clarify the relationship between neurobiological, genetic, and clinical observations in the field of suicide study. Understanding the complex interplay of psychological, biological, sociobiological, and clinical risk factors is essential for developing effective preventative approach plans for suicidal ideation and suicide.