Background: Parental awareness and knowledge play a pivotal role in early recognition, prevention, and care of common pediatric infections. This study aimed to assess the knowledge and awareness of parents in Chamba, Himachal Pradesh, regarding common pediatric infections and their prevention.Material and Methods:This descriptive, cross-sectional study was conducted from August to October 2024 in Chamba, Himachal Pradesh. A total of 400 parents, selected through stratified random sampling, participated in the study. Data were collected using a structured, pre-validated questionnaire comprising two sections: socio-demographic variables and knowledge assessment of pediatric infections. Knowledge scores were categorized into four levels: very good (>80% correct responses), good (60–79%), fair (41–59%), and poor (<40%). Data analysis was performed using descriptive statistics and chi-square tests for associations.Results: The study included 55% mothers and 45% fathers, with 67% residing in rural areas. The majority of participants were aged 26–45 years (67%), and 27% had secondary-level education. Awareness of key preventive measures, such as routine vaccinations (84.5%) and exclusive breastfeeding (82.5%), was high. However, knowledge of specific symptoms of pediatric infections, such as rash for measles (65%) and persistent cough for pneumonia (69%), was moderate. Overall, 29.5% demonstrated very good knowledge, 36% scored good, while 24% and 10.5% fell into the fair and poor categories, respectively. Barriers to knowledge included geographic isolation, limited education, and misconceptions about infection causes and treatments.Conclusion: This study highlights a foundational understanding of pediatric infection prevention among parents in Chamba while identifying critical gaps in knowledge related to symptoms and treatment. Targeted, community-based educational interventions, strengthened immunization programs, and increased access to healthcare resources are essential to bridge these gaps and improve child health outcomes. Engaging community health workers and leveraging digital platforms can further enhance the effectiveness of these initiatives.