Background: Successful wound treatment depends upon the use of adequate local agents and well selected dressing which reduce the bacterial load, reduce slough, promote granulation and induce early wound closure. The present study was conducted to evaluate the efficacy of PDGF dressing diabetic foot ulcers. Materials and Methods: 60 patients having diabetic foot ulcer (fulfilling the inclusion criteria and without any of exclusion criteria) reporting in the indoor as well as outdoor of Department of Surgery, Government Medical College & Hospital, Chandigarh were selected and divided into two groups of 30 patients each. After cleaning the wound surface with and removing any slough or necrotic tissue present over the wound surface, PDGF dressing was applied and covered with a dry sterilized gauze piece and a bandage. The dressing was changed every day and the wound inspected to record change in the size of the wound. The PDGF dressing was applied over the wound surface up to a maximum period of 12 weeks. Results: The majority of people affected with diabetic foot was above the age of 50 years and were males. Most of the patients affected were having long standing and poorly controlled diabetes. Among the affected 20 % patients only showed bony changes on x-ray in the form of loss of foot arches. In both the groups more than 80 % patients had sensory losses in the foot. The culture trends in both the groups showed predominance of gram negative bacilli mostly Klebsiella and Proteus. Most of the patients affected were in the overweight category with increased BMI. The mean healing rate in the study group was significantly high compared to the control group at 86% as compared to 72% in the control group. Conclusion: This study concluded that healing in diabetic foot ulcers when subjected to treatment with PDGF showed better healing rates as compared to the control group. The study also concluded that diabetic foot ulcers were associated with poor self-care, poorly controlled diabetes, obesity and increasing age and increased duration of diabetes.