Background: Insulin resistance is a critical factor in the pathogenesis of metabolic syndrome, a cluster of conditions that significantly increases the risk of cardiovascular disease and type 2 diabetes. Early identification and prevention of insulin resistance are essential to delay or prevent the onset of metabolic syndrome. Objective: This review aims to summarize current strategies for the prevention of insulin resistance, with a focus on lifestyle modifications, pharmacological interventions, and emerging therapies. Methods: A comprehensive literature review was conducted, analyzing studies and clinical trials that focus on the prevention of insulin resistance. Key databases were searched, and articles were selected based on relevance and contribution to the topic. Results: Effective prevention strategies for insulin resistance include dietary modifications, regular physical activity, and weight management. Pharmacological interventions such as metformin and thiazolidinediones have shown promise in reducing insulin resistance, particularly in high-risk populations. Conclusion: Preventing insulin resistance before the development of metabolic syndrome is crucial for reducing the burden of cardiovascular disease and type 2 diabetes. Early intervention through lifestyle changes and targeted therapies offers the best approach to mitigating the progression of insulin resistance.