Background: Hemorrhoids, a common medical condition characterized by the swelling of blood vessels in the rectal and anal region, significantly impact individuals' quality of life. Despite their prevalence, misconceptions and knowledge gaps about hemorrhoids persist globally. This study aimed to assess awareness and knowledge levels regarding hemorrhoids among the general population of Lima, Peru, where healthcare access varies across diverse cultural landscapes. Materials and Methods: A cross-sectional survey involving 400 adults residing in Lima was conducted between March and May 2023. Participants completed a structured questionnaire covering demographics and 20 knowledge-related questions about hemorrhoids. Data were analyzed using Epi Info V7 software. Results: The study revealed varying levels of awareness and knowledge among participants. While 70.25% correctly identified hemorrhoids and 69.75% knew their anatomical location, only 40% correctly identified potential causes. Awareness was relatively higher for symptoms and consequences, with 69% correctly identifying common symptoms and 71.25% recognizing the need for medical attention. Misconceptions about causes were evident. In terms of management, 62.5% recognized preventive measures but only 58.25% knew about over-the-counter medications. The majority (71.25%) knew when to seek medical attention and 59.75% were aware of non-surgical treatment options. Conclusion: The study highlights the need for targeted public health initiatives in Lima, Peru, to improve hemorrhoid awareness and knowledge. Bridging knowledge gaps and clarifying misconceptions through educational campaigns and accessible healthcare information resources is crucial. Enhancing understanding can promote early detection, timely intervention and improved quality of life for individuals affected by this common condition.