A Randomized Control Study to Compare the Change in the Mean Packed Cell Volume after Intravenous Ferric Carboxymaltose and Iron Sucrose in the Treatment of Iron Deficiency Anemia in Pregnancy
Background: The goal of the current study was to assess how the mean packed cell volume changed following intravenous administration of ferric carboxymaltose and iron sucrose for the treatment of iron deficiency anaemia in pregnancy. Materials and Methods: Between June 1 and May 31, 2020, a prospective study was carried out in the department of obstetrics and gynaecology at the Kamla Nehru State Hospital for Mother and Child, Indira Gandhi Medical College Shimla. The study involved 86 pregnant women with iron deficiency anaemia. The participants were randomly divided into two equal groups, one of which got iron sucrose intravenously and the other, ferric carboxymaltose. At 2 and 4 weeks of follow-up, the treatment's effectiveness in terms of mean packed cell volume was evaluated. Results: Maximum subjects were in age group 21–25 years and belong to lower middle class according to modified Kuppuswamy scale in both groups. In group A, the mean value of baseline packed cell volume was found to be 25.6 % while in group B, the mean value of baseline packed cell volume was found to be 25.26%. The baseline mean packed cell volume (p-value = 0.505) was comparable in group A and B. The mean value in packed cell volume at 2 weeks of follow up was 33.64 % in FCM group and 31.02 % in ISC group. At 4 weeks post infusion the mean packed cell volume was 37.11% in FCM group whereas it was 34.17% in ISC group. Conclusion: At both the follow up visits the increase in packed cell volume was higher in FCM group compared to ISC group which was statistically significant. (p <0.001).