In the vast kingdom of antibiotics, Ciprofloxacin is one of the common family, having significant absorption activity. The principal target of this research has been settled to monitor the redox behavior of Cu (II) and Cr (III) in potassium chloride before and after interaction with ciprofloxacin involving three prominent electrochemical techniques such as cyclic voltammetry, chronoamperomety and chronocoulometry. To perform this work, Cu (II) and ciprofloxacin equimolar solution was mixed to a 1:1 ratio but Cr (III) and Ciprofloxacin solution to a 1:2 ratio. Then after interaction those were analyzed in solution. The observations for Cu (II) as well as Cu (II)-ciprofloxacin interaction systems showed that the redox couple involved in both the cases were quasireversible. But the Cr (III) system, before and after interaction, showed reversible and irreversible behaviour respectively. After interaction with ciprofloxacin, the chronoamperometric study showed that the rate of electrolysis for both the metal systems were decreased and the charges at τ values are also decreased in all the cases which were assigned from the chronocoulometry. These facts together indicated towards successful interaction between the metals and ciprofloxacin. Again after interaction, adsorption of reactant or products occur on the electrode, which was found from the plots Q vs t1/2 and -Qr vs θ. To conclude, it can be said that the significant activities of the metal-ciprofloxacin interaction may be employed as a basis in the field of medicine.