The protective effects of aqueous leaf extracts of Jatropha curcas (JC) and Hibiscus sabdariffa (HS) against hepatic toxicity resulting from lead acetate exposure were studied. The protective potentials of JC and HS were assessed by monitoring selected liver function and anti-oxidant indices. Sixty male Wistar rats were separated into ten equal groups. The first and second groups represented the normal and Lead acetate (PbA) (50mg/kg b.w) control groups respectively while groups 3 and 4 were given 100mg/kg JC and 200 mg/kg JC respectively. Groups 5 and 6 received 250 mg/kg HS and 500 mg/kg HS respectively. Groups 7-10 were given PbA (50mg/kg) and 100 mg/kg JC, 200 mg/kg JC, 250mg/kg HS, 500mg/kg HS respectively. Rats were orally administered their relevant doses for 28 days. Blood samples were collected from heart puncture at the end of the experiment (28 days) for hepatic function analysis. Results revealed that Pb exposure increased the gamma glutamyl transferase, total bilirubin, aminotransferase activities (AST and ALT), and malondialdehyde (MDA) levels and caused histological changes in the liver of the exposed rat groups. The concomitant treatment of PbA with aqueous extracts of JC and HS led to a significant protection from the deleterious effects of lead acetate.