This paper explores the use of 4 helix innovation strategies in the Blue Growth sector.Data from a pilot in 8 Mediterranean regions is explored to analyze its results and the applicability in other regions or other sectors. It took place between 2018 and 2020 and included eight different pilot regions: Lisboa in Portugal, Seville and Barcelona in Spain, Marseille in France, Ancona in Italy, Tirana in Albania, Zadar in Croatia and Thessaloniki in Greece.In each of these regions, six 10 thousand-euro (€10k) vouchers were attributed to innovation projects in the Blue Growth sector, in a total of 48 vouchers and a €480.000 investment. These vouchers were attributed to projects submitted by partnerships of one Blue Growth SME and one Knowledge Provider (KP) from either the Cultural Creative Industry or from other research facilities.Main Findings: In the end, all projects were completed, and the satisfaction of all participants was later analyzed. Open innovation strategies gathering inputs from all 4 helices offer positive results measured in new innovations marketed by SMEs and startups. These strategies require dynamic ecosystems functioning in their support.The results from this Interreg MED supported project support the use of innovation vouchers to increase innovation in specific sectors or regions. It also supports the use of 4 helix innovation strategies.