Regional anesthetic technique especially upper extremity surgery with using clonidine, opioids, tramadol, corticosteroid for prolongation of anesthesia and analgesia. When administered as adjunct to Clonidine with Dexamethasone adjuvant to Bupivacaine and Lignocain with adrenaline observed early onset and prolong duration of analgesia in interscalene brachial plexus block. Aim and objective is to compare the effect of addition of dexamethasone and clonidine to local anesthetic drug in (0.5% Bupivacaine+ 2% lignocaine with adrenaline) in peripheral nerve stimulator guided Interscalene brachial plexus block. Methodology: 90 patients presenting for upper limb surgery were in three groups. Group D receiving Dexamethasone 8 mg.  as an adjuvant to Bupivacaine and lignocaine whereas Group C receiving Clonidine 75 mcg. as an adjuvant to bupivacaine and lignocaine and Group S as control group receiving saline as an adjuvant to bupivacaine and lignocaine with adrenaline in interscalene brachial plexus block. Results: The mean duration of motor block in group S was 5.74±0.384 hrs, whereas in group C was 8.86±0.846 hrs, and group D was 9.32±0.964 hrs on comparison showing significant difference. The mean duration of sensory block in group S was 6.86±0.38 hrs, in group C was 9.86±0.98 hrs, and group D was 10.68±0.88 hrs. with significant difference between the group. Onset of sensory and motor block was better in dexamethasone D group. Conclusions: The study conclude that dexamethasone added to bupivacaine plus lignocaine showing better efficacy in prolonging analgesia than clonidine and control group with better hemodynamic with no side effects.