srjmsSRJMSSRJMS2788-948310.47310/srjms.2025.v05i01.016Effect of Baclofen on Lower Urinary Tract Symptoms in Different Age GroupsAhmedA. EssaAssistant Professor of urology, Iraqia University, IraqThe following study meticulously investigated the impacts of baclofen on lower urinary tract symptoms in males and females less than and greater than 50 years of age. Baclofen is an agonist to GABA B receptors, mainly used in treating muscle spasticity, but also shown to affect bladder function. This study aimed to establish whether baclofen can reduce urgency, frequency, and overactivity symptoms of the bladder in subjects from different demographics. Quantitatively, ANOVA has been done to compare three groups of data: males and females below 50, males above 50, and females above 50. It was found that there is a significant difference between pre- and post-therapy urinary tract functions, with baclofen having maximum effect on males and females in the higher age group. Results showed the efficiency of the drug baclofen in treating lower urinary tract function but with high predisposition in adults over 50 years. In addition, differences regarding responses between ages and gender showed the need to consider different options for individual patients. The research underlines that gender and age are very relevant when the prescription of baclofen is recommended for symptoms within the lower urinary tract. More studies are necessary to look into combination treatments and long-term effects with a view to maximizing therapeutic benefits.