iarjimphIARJIMPHIARJIMPH2709-331Xhttps://doi.org/10.47310/iarjimph.2025.v06i01.014Changes In Serum Levels of Calcitonin Gene-Related Peptide in Pregnant Women with Gestational Diabetes MellitusBackground: Gestational diabetes mellitus (GDM) is the impaired carbohydrate metabolism first diagnosed in pregnancy, which may lead to serious health problems for the mother and her fetus. Aim: The aim of this study was to determine calcitonin gene-related peptide (CGRP) levels in pregnant women with GDM. In addition, it was aimed to determine whether serum CGRP level is associated with adiponectin level. Patients and Methods: The case-control study was carried out in Tikrit city (Salah Al-Din General Hospital) from 15th of January to the end of December 2022. The number of pregnant women understudy were 100 women in the 3rd trimester of pregnancy whose ages were between 20-45 years old who attended Salah Al-Din General Hospital /Obstetric part. The study also included 50 healthy non-diabetic pregnant women in 3rd trimester of pregnancy ages were between 20-45 years as control group. Medical information, such as maternal age, gravida, parity, number of abortions, reproductive and medical history was obtained from patient files. Blood samples were collected for assessment of HbA1c, blood sugar, calcitonin gene-related peptide (CGRP) and adiponectin levels. Results: The study showed the mean of CGRP was elevated significantly in GDM group (8.04 pg/ml) compared with women without GDM control group (2.91 pg/ml) (P:0.001). The study showed the mean of adiponectin was reduced significantly in GDM group (77.89) compared with women without GDM control group (99.72 pg/ml) (P:0.001). It was found that HbA1c was elevated significantly in GDM women (5.91%) and the lowest mean was non-GDM women (5.21%) and fasting blood sugar was also elevated significantly in GDM women (135.3 mg/dl) and the lowest mean was non-GDM women (91.35 mg/dl). The study showed positive correlation of CGRP serum level with each of FBS, HbA1c and Gestational age and negative correlation with serum Adiponectin among women with gestational diabetes. Conclusions: Serum CGRP levels were increased significantly inpregnant women with GDM compared with women without GDM control group and the outcomes of this investigation suggest that high CGRP levels in pregnant women may be a pivotal role in the natural history of GDM.