iajabmsIAJABMSIAJABMS2709-329810.47310/iajabms.2025.v06i01.009Management of Tennis Elbow with Local Platelet-Rich Plasma Injection: An Evidence-Based Review of Clinical Outcomes and AdvancesBackground: Tennis elbow, or lateral epicondylitis, is a degenerative tendinopathy of the extensor carpi radialis brevis tendon. Traditional management options such as corticosteroid injections provide temporary relief but are associated with recurrence and tendon degeneration. Platelet-rich plasma (PRP) therapy has emerged as a regenerative alternative aiming to promote tendon healing. Objective: To elaborate on the clinical evidence supporting PRP therapy in tennis elbow, compare its efficacy with corticosteroid injections, and highlight recent advancements in PRP preparation and administration. Material and Methods: An evidence-based review was conducted through a synthesis of recent randomized controlled trials, systematic reviews, and meta-analyses evaluating PRP therapy for lateral epicondylitis. Results: PRP therapy demonstrated superior long-term outcomes compared to corticosteroids, including sustained pain relief and improved functional scores. Emerging techniques such as leukocyte-poor PRP formulations and combined scaffold-assisted PRP injections further enhance therapeutic outcomes. Ultrasound-guided injections optimize PRP delivery to affected tendinous regions. Conclusion: Platelet-rich plasma injection is an effective and promising treatment for chronic tennis elbow, offering regenerative healing and durable clinical benefits. Ongoing innovations are expected to refine its role further in musculoskeletal regenerative medicine.