iajabmsIAJABMSIAJABMS2709-329810.47310/iajabms.2025.v06i01.001Design, Synthesis, and Evaluation of 1,2,3-Triazolylmethyl Carbazoles as potent Antibacterial ActivitiesI. AlrubaieMuhandDohanAbidMustafaKadhumNaeemAliJabbarRadhiJabir Ibn Hayyan University for Medical and Pharmaceutical Sciences, Faculty of Pharmacy, Najaf, Iraq.Jabir Ibn Hayyan University for Medical and Pharmaceutical Sciences, Faculty of Medical Science, Najaf, Iraq.University of Alkafeel, Faculty of Pharmacy, Najaf, Iraq.Despite extensive efforts to manage infections, bacterial resistance continues to pose a serious concern and rank among the world's leading causes of mortality. Seven new Pyridyl-functionalized 1,2,3-triazoles connected to carbazole components were created using the Cu(I)-catalyzed alkyne-azide cycloaddition CuAAC of substituted-pyridyl azides with a variety of alkyne-functionalized sugars in an attempt to create physiologically active antibacterial drugs. Several spectroscopic methods were used to confirm the novel derivatives' chemical structures. The new clicked 1,2,3-triazoles were tested for in vitro antibacterial activity against two Gram-negative bacterial strains, namely Escherichia coli (MTCC43) and Klebsiella pneumonia (MTCC530), as well as Hay bacillus (MTCC 121) and staph (MTCC96). The results were compared to the activity of the control antibiotic, "Ampicillin." Using the disc assay, compounds (2g, 2f, and 2c) exhibit a considerable zone of inhibition against E. coli and K. pneumonia (24, 22, and 24 mm) and (26, 24, and 21 mm), respectively. Based on the results, it can be said that compound (2g and 2f) has stronger antibacterial activity against B. subtilis and S. aureus than the reference medication.