srjcmsSRJCMSSRJCMS2788-885110.47310/srjcms.2024.v04.i02.014Study of the biochemical and hormonal changes among men with prostate cancer in Kirkuk city, IraqYildizHasanTahseenAhmedMaterSailh WasmeAssist. Prof. Biochemistry Branch, Kirkuk Medical College, University of Kirkuk, IraqAffiliation: Biochemistry Branch, Kirkuk Medical College/University of Kirkuk.Background and objectives: Prostate cancer is the primary cause of cancer-related deaths in males; rates range over 25 times globally, with North America, Western and Northern Europe, Australia, and New Zealand having the highest rates. Aim of the study: To study the hormonal and biochemical changes in these patients before and after chemotherapy.  Materials and Methods: The current study is a retrospective observational study was executed in Oncology center/Kirkuk, Iraq from January 25th to July 26th 2024  on 255 patients with mean age (62.07) years and prostate cancer. The patients were tracked on in two different time points, before and after getting chemotherapy. Their hormones and biochemical measured. Results: The present study revealed significant increasing in the LH concentration (25.23 IU/L), this was also true for FSH concentration (30.15 IU/L), Cortisol level (19.62µg/dl), Insulin level (22.77 µIU/ml) and PTH mean level (42.32 pg/ml) after chemotherapy in patients. Moreover the present study displayed significant decreasing in the mean levels of PSA (4.05 ng/ml), Testosterone (57.52 ng/dl) and PAP (2.46 U/L) after treatment. Cholesterol, Glucose, ALP, and LDH levels declined significantly post treatment.   Conclusions: Older ages are more prone to get prostate cancer. Chemotherapy therapy has effective impact on dropping the levels of some hormones and biochemical elements among prostate cancer patients.