srjmcrSRJMCRSRJMCR2788-954810.47310/srjmcr.2024.v0i403.002Evaluation level of oxidative stress and antioxidant in polycystic ovary women in Tikrit CityRuaaHusseinAlwanAlalam Education Department, General Direction Of Education in Salah al-Din, IraqBackground: Polycystic ovary (PCOS) is the most frequent endocrine condition among reproductive-aged women. Aim of the study: To determine the LH, FSH, Testosterone , HbA1c, antioxidant status and oxidative stress of females with polycystic ovarian syndrome. Materials and methods: This study From December 2023 to April 2024, Tikrit Governorate collected 90 samples (60 POC women and 30 healthy women) from 60 female patients (15–45 years old) with severe polycystic ovary syndrome. A control group of 30 ladies without polycystic ovary syndrome was also included. Both groups were tested for Glutathione (GSH) and Malondialdehyde (MDA) , HbA1c Luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone. Result: The study found higher levels of LH, Testosterone, and HbA1c in women with PCOs (11.26±4.58, 0.93±1.77, 5.54±0.47) compared to healthy women (5.71± 3.95, 0.38±0.2, 4.12±0.73) at p-value <0.05. There were no significant variations in FSH levels between women with PCOs (8.11±3.15, 8.75± 2.91) and healthy women (p-value >0.05). Serum GSH levels in women with PCOS were lower than those in healthy women (15.49±2.99 vs. 21.93±3.14), with p-value< 0.05.Vitamin C levels were lower in PCOS women compared to healthy women (1.13±0.13, 1.25±0.19), p-value < 0.05. In PCOS, MDA levels were higher than in healthy women (31.67±3.53, 17.23±1.23), with p-value > 0.05. Conclusion: Antioxidants may serve as a beneficial adjunct therapy in the management of polycystic ovarian syndrome, perhaps mitigating oxidative damage and addressing metabolic and reproductive abnormalities linked to infertility in this condition.