iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2024.v05i02.006Modification of Amoxicillin Drug Antibacterial to Promising Anti-Breast Cancer MCF-7 Imine Derivatives: Synthesis and In Vitro StudiesN. AhmedMahmoodTasnimTariqMohammedRehamNajemAbdulridhaAulaHassoonObaidK. AbbasAbbasCollage of Medicine, University of Fallujah, Al-Anbar, IraqCollege of Dentistry, Waist University, Republic of Iraq, Waist, IraqMuthana Agriculture Directorate, Ministry of Agriculture, Al-Muthana, IraqIn this study, we report a novel imine derivatives synthesis (A and B) by reacting pure amoxicillin drugs with 2-aminobenzaldehyde and 2-methylbenzaldehyde. Spectroscopic techniques, such as FT‐IR spectroscopy, characterized the derivatives (A and B). All the synthesized derivatives (A and B) were evaluated in vitro against microorganisms such as Bacillus subtilis and E. coli by zone inhibition method and screened for antimicrobial activities and anti-breast cancer MCF-7 cell viability cell lines.