iarmsIARMSIARMS2709-3255https://doi.org/10.47310/iarms.2020.v01i01.002The Significant and Profound Impacts of the Studies on the Rate of Diffusion-Controlled Reactions of EnzymeAbout 47 years ago a very important paper on the rate of diffusion-controlled reactions of enzyme was published. According to its deduction, the upper limit of enzyme-substrate reaction is 1010/Msec, which is one order of magnitude higher than the conventional estimation by Manfred Eigen, who won the 1967 Nobel Prize in Chemistry for the work on measuring fast chemical reactions.    The new upper limit has been confirmed by a series of follow-up studies [1,2,3,4,5,6,7,8,9,10,11,12].  It is indeed very significant and profound for such a breakthrough or revolution in enzyme fast reaction. Particularly, it has also been supported by the eight masterpiece papers of the then Chairman of the Nobel Prize Committee (see, e.g.., [8,9;13,14,10,14].