iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2022.v03i02.023Analysis of Receiver Operating Characteristic (ROC) Curve Based on Suvmax (Standardised Uptake Value Maximum) and Biopsy Results in Prostate Cancer PatientsViperSharma Dr. SunilKumarRishabhChadhaBackground: The present study was done for the Analysis of Receiver Operating Characteristic (ROC) curve based on Standardised Uptake value Maximum (SUVmax) and biopsy results in Prostate Cancer Patients. Material and Methods: Forty four patients with suspected PCa on clinical assessment and/or raised serum PSA levels (>4ng/mL) were prospectively recruited. Patient who underwent prostatic biopsy prior to 68Ga-PSMA PET/CT and mpMRI, deranged renal function tests or coagulogram and refused consent were excluded. Forty four patients underwent 68Ga-PSMA PET/CT and 33 patients underwent biopsy. Any focal tracer uptake on 68Ga-PSMA PET/CT was regarded as pathological. Histopathology was taken as gold standard. SUVmaxof the lesions were measured for quantization. Results: Mean age of patients was 66.61±9.3 years and median PSA level was 13.4 ng/mL (IQR 13.9). Malignancy was detected in 16/33 (48.5%) patients who underwent biopsy. The median SUVmax for cases with confirmed malignancy (n = 16) was found out to be 17.6 (IQR 18.9). Median SUVmax for cases with no evidence of malignancy was 6.3 (IQR 2.80). The difference between the two groups was found to be statistically significant (Mann Whitney U test, p = 0.002). On evaluation of Receiver Operating Characteristics (ROC) curve, area under the curve was 0.818. It was found that at cut off value of 10.4 for SUVmax, the sensitivity of 68Ga PSMA PET/CT was 75% and specificity was 94.1%. It was observed that median of the SUVmax was same across categories of biopsy. Conclusion: The present study concluded that SUVmax cut-off of 10.4 on 68Ga PSMA PET/CT can detect PCa with a sensitivity of 75% and specificity of 94.1%.