iarjmsIARJMSIARJMS2708-359410.47310/iarjms.2022.v03i02.019Intra & Post-operative Hemodyanamic Variables in Ultrasound Guided 4-in-1 Nerve Block with Bupivacaine in Combination with Dexmedetomidine in Two Doses for Knee and Below Knee Orthopaedic SurgeriesIshaKhanUrvashiNautiyalNeetikshaMedical Officer Specialist at ESI ParwanooMedical Officer Specialist at SLBSGMC Ner Chowk MandiMedical Officer Specialist at Pt.JLNGMC ChambaBackground: The goal of the current study was to examine the hemodyanamic variables both intraoperatively and postoperatively in ultrasound guided 4-in-1 nerve blocks using bupivacaine and dexmedetomidine in combination across two doses for knee and below knee orthopaedic operations.Material & Methods: A comparative study was carried out among patients planned to undergo knee and below knee surgeries under SAB. A total of 100 patients were randomly divided into 2 groups. Group A was given 29 ml of 0.125% bupivacaine with 0.5µg/kg dose of dexmedetomidine (1ml) making it to a total 30 ml solution, in USG guided 4 in 1 block while Group B was given 29 ml of 0.125% bupivacaine with 1µg/kg dose of dexmedetomidine (1ml) making it to a total 30 ml solution, in USG guided 4 in 1 block.Results: In this study, mean intraoperative heart rate from baseline to 120 min was comparable between both groups and statistically non-significant(P>0.05), mean intraoperative systolic BP from baseline to 120 min was comparable between both groups and statistically non-significant (P>0.05), mean intraoperative diastolic BP from baseline to 120 min was comparable between both groups and statistically non-significant(P>0.05) and mean intraoperative SPO2 from baseline to 120 min was comparable between both groups which was statistically non-significant(P>0.05). Similary ,In the present study, oxygen saturation from 0-hour to 24-hour post administration of 4- in -1 block was comparable between both groups (P>0.05) and was statistically non-significant, mean heart rate from 0-hour to 24-hour post administration of 4- in -1 block was comparable between both the groups and was statistically non-significant(P>0.05) and mean systolic BP from 0-hour to 24-hour post administration of 4- in -1 block was comparable between both the groups and statistically non-significant(P>0.05).Conclusion: The study concluded that both groups were comparable in terms of intraoperative and post-block hemodynamic variables such as heart rate, systolic and diastolic BP, and oxygen saturation.