iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2022.v03i02.013Evaluation of Efficacy and Safety of Intravenous Iron Sucrosein the Treatment of Iron Deficiency Anemia in PregnancyAnkitaThakurBishanDhimanNishiSoodSudarshanSharmaSidharathSoodDepartment of Obstetrics and Gynaecology, Kamla Nehru Hospital, IGMC, Shimla, (H. P.), IndiaDepartment of Pathology, IGMC Shimla, Himachal Pradesh, IndiaDepartment of Orthopaedics, IGMC Shimla, Himachal Pradesh, IndiaBackground: Iron deficiency anemia during pregnancy is associated with an increased risk of low birth weight, preterm birth, maternal and perinatal mortality and poor Apgar score. The present study was done with the objective to evaluate the efficacy and safety ofIntravenous Iron Sucrose in the treatment of iron deficiency anemia in pregnancy. Materials and Methods: This was a prospective study conducted in the department of Obstetrics and Gynaecology, Kamla Nehru State Hospital for Mother and Child, Indira Gandhi Medical College Shimla from 1st June 2019 to 31st May 2020. Forty three antenatal women with iron deficiency anemia were included in the study. The subjects were given intravenous Iron Sucrose and Response of treatment in terms of hemoglobin, packed cell volume, serum iron, serum ferritin and total iron binding capacity was assessed at 2 and 4 weeks on follow up. Results: In our study, it was observed that maximum subjects were in the age group of 21-25 years and belonged to class III (lower middle class) according to modified Kuppuswamy scale (69.8%).Out of 43 participants, 25.6% received dose of ISC between 801-850 mg. The mean dose of ISC was 831.26 mg. The mean value of baseline hemoglobin, reticulocyte count, packed cell volume, serum iron, serum ferritin and total iron binding capacity was found to be 8.36 g/dL, 0.74%, 25.26%, 36.17 ug/dL, 10.514 ng/dL and 493.460 ug/dL respectively. The mean value of hemoglobin, reticulocyte count, packed cell volume, serum iron, serum ferritin and total iron binding capacity at two weeks post infusion was found to be 10.03 g/dL, 2.228%, 31.021%, 92.758 ug/dL, 116.114 ng/dL and 410.61 ug/dL respectively. The mean value of haemoglobin, reticulocyte count, packed cell volume, serum iron, serum ferritin and total iron binding capacity at four weeks was found to be 11.002 g/dL, 2.507%, 34.17%, 111.03 ug/dL, 96.367 ng/dL and 380.540 ug/dL respectively. There was a very strong evidence against null hypothesis and there was significant difference in all the parametersat four weeks (p<0.001). Conclusion: The present study concluded that intravenous iron sucrose is efficacious in replenishment of iron stores in a short duration of time and improvement of hemoglobin levels and had good safety profile.