iarjhcpIARJHCPIARJHCP2789-6048https://doi.org/10.47310/iarjhcp.2022.v02i02.005Scrub Typhus: Mode of Transmission, Clinical Features, Investigations, Treatment, Differential Diagnosis, Preventive Measures & PrognosisVineetBhardwajAssemSirkeckKamalKantKaliaScrub typhus is an acute febrile illness in the “tsutsugamushi triangle”, caused by the parasite Orientia tsutsugamushi and is transmitted to humans by the bite of certain kinds of trombiculid mites, or chiggers. Scrub typhus is manifested clinically by high fever, intense generalized headache, diffuse myalgias, and, in many patients, rash and an eschar at the site of the chigger bite. Laboratory testing, including molecular and serological assays, is needed for confirming the diagnosis, especially in the absence of the pathognomonic eschar. In this review, factors that play a role in disease occurrence, clinical features, investigations, treatment, differential diagnosis, Preventive measures, prognosis etc are also enumerated and described.