iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2022.v03i01.043Vascular endothelial growth factor (VEGF): A Noninvasive Biomarker for the Prediction of Invasive PlacentationShaimaaSabriAthabSuraSaladdinSalmanFarahAbdul MajedSalmanBackground: Abnormally Invasive Placentation (AIP) is a life-threatening obstetric condition which is responsible for massive obstetric hemorrhage that is a leading cause of pregnancy related death. The optimal management of this complication requires a valid antenatal diagnostic tool other than Doppler Ultrasound (US). Of these, a handful of laboratory markers have been so far used for the antenatal detection of invasive placentation. Objective: This study sought to establish whether low maternal serum VEGF is related to AIP. Materials and Methods: Over a period of 0ne year, a case control study was conducted in the department of Obstetrics and Gynecology at AL-Yarmouk Teaching Hospital, including 90 pregnant ladies with gestational age 28 week and beyond, of whom 43 cases were diagnosed with placenta accrete using Doppler ultrasound and 47 healthy pregnant ladies with normal placentation. The serum vascular endothelial growth factor was measured by Enzyme-linked immunosorbent assays in all participants and each individual was followed up regarding intraoperative and postoperative outcomes. Results: A significantly lower serum vascular endothelial growth factor level was found in women having placenta accrete when compared with control group with (p<0.001). At a level of 95.85 pg/mL, serum vascular endothelial growth factor was 90% sensitive, 64% specific in the identification of cases with placenta accrete spectrum. Conclusion: Vascular endothelial growth factor levels may be a potential noninvasive biomarker to aid in the antepartum diagnosis of invasive placentation.