iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2022.v03i01.004Comparison of C-reactive protein & Vitamin D3 level among Patients of Allergic Rhinitis while on treatment with either Nasal Fluticasone or Combination Therapy of Montelukast and Levocetirizine: A Randomized Control StudyRishabhChadhaJeevankumarBackground: We conducted the present study to compare the vitamin D3 status and C-reactive protein (CRP) among allergic rhinitis patients who were on treatment with either intranasal Fluticasone or oral Levocetrizine and Montelukast therapy. Material and Methods: The study was a prospective randomized, single blinded, comparative, parallel group study, with two intervention groups conducted at Civil Hospital Jogindernagar of Himachal Pradesh, India. A total of Fifty patients diagnosed with allergic rhinitis was randomly allocated to either Group A receiving oral Montelukast and Levocetrizine or Group B receiving Fluticasone propionate aqueous nasal spray and followed up for 6 weeks. Vitamin D status and C-reactive protein (CRP) after 6 weeks was taken as primary outcome variables. Results: Among Group A, Recovery at 6 weeks was occurred in 9 (36%) patients while in Group B Recovery at 6 weeks was occurred in 17(68 %) patients (p value 0.046). There was statistically significant lower mean CRP level was found in group B as compared to Group A (p value 0.003). Although, lower mean Vitamin D3 level was found in group B as compared to Group A but this difference was not found to be statistically significant. (p value 0.218). Although, lower mean CRP and higher mean Vitamin D3 level was found in recovered patients in group A as compared to who were not recovered but this difference was not found to be statistically significant (p value 0.198 and 0.324 respectively).  Similarly, higher mean CRP and Vitamin D3 level was found in recovered patients in group B as compared to who were not recovered but this difference was not found to be statistically significant. (p value 0.804 and p value 0.418). Similarly, in recovered patients there was no statistically significant difference in mean CRP and Vitamin D3 level (p value 0.9536 and 0.2486 respectively) in both groups, although the mean CRP and Vitamin D3 level were higher in Group A as compared to group B. But in non-recovered patients, the mean CRP level was statistically higher in Group A as compared to group B (p value0.0029) while there was no statistically significant difference in Vitamin D3 level in both groups (p value-0.8919). Conclusion: Study concluded that there was no statistically significant difference in mean Vitamin D3 and CRP levels in both groups as well as there was no significant association between Vitamin D3 and CRP levels and recovery status of patients in both groups.