iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2021.v02i02.032The Effect of Vitamin C Administration on Contrast-Induced Nephropathy in Diabetic Foot Ulcer Patients Performing Digital Subtraction AngiographyAuliaThabraniDarmawanIsmailIdaBagusBudhiThe prevalence of diabetic foot ulcers in the world in 2016 was 6.3%. Digital Subtraction Angiography is the standard contrast angiography examination. Contrast-Induced Nephropathy is a complication of angiographic procedures. Vitamin C from various studies has a role in preventing the occurrence of Contrast-Induced Nephropathy. The purpose of this study was to determine the effect of giving Vitamin C on the incidence of Contrast-Induced Nephropathy. This study used a quasi-experimental design using a two-group pretest-posttest control-group design. It was conducted in the sub-section of Cardiovascular Thoracic Surgery, dr. Moewardi General Hospital Surakarta from June to July 2021. Data were analyzed using the paired sample t-test and the related samples Wilcoxon signed-rank test. The results of statistical analysis showed a p-value of<0.05 for Group B’s creatinine and e-GFR variables. Meanwhile, for Group A’s creatinine and Group A’s e-GFR, there was no significant difference with p>0.05. This shows that there is an incidence of CIN in Group B because there is an increase in serum creatinine and e-GFR. Vitamin C can maintain serum creatinine and GFR in normal conditions. This indicates that vitamin C can prevent the occurrence of Contrast-Induced Nephropathy.