iarjmsIARJMSIARJMS2708-359410.47310/iarjms.2021.v02i02.018Comparing the Retinal Nerve Fibre Thickness and Corneal Endothelial Morphometric Changes Among the Residents Living In High Altitude: A Cross-Sectional Analytical Study in a Tertiary Medical College Of Trans-Himalayan RegionSharmaSSharmaVSharmaRLResident, Department of Ophthalmology, IGMC Shimla, Himachal Pradesh, IndiaAssociate Professor, Department of Ophthalmology, IGMC Shimla, Himachal Pradesh India.Professor & Head, Department of Ophthalmology, IGMC Shimla, Himachal Pradesh, IndiaPseudoexfoliation (PEX) is an age-related idiopathic condition characterized by progressive production and accumulation of extracellular matrix fibrillary material in the intraocular and extraocular tissues. Ocular involvement in PEX primarily manifests with anterior segment findings. The objective of the study was to estimate the retinal nerve fibre layer (RNFL) thickness in patients of pseudoexfoliation with (PEXG) and without glaucoma (PEX) by optical coherence tomography (OCT) and determine the corneal endothelial morphometric changes by Non-contact Specular Microscope in patients of pseudoexfoliation with (PEXG) and without glaucoma (PEX). This cross-sectional analytical study was conducted in the Department of Ophthalmology, Indira Gandhi Medical College, Shimla among the selected patients of pseudoexfoliation with and without glaucoma over a period of one year. We included normal healthy controls without any glaucomatous optic disc damages and an IOP <21 mmHg in group 1, patients clinically diagnosed as pseudoexfoliation without glaucoma (PEX) in group 2, and Patients already diagnosed as pseudoexfoliative glaucoma(PEXG) in group 3. RNFL thickness was significantly decreased in PEX and PEXG patients and endothelial cell density was decreased, pleomorphism and polymegathism of cells were increased, and pseudo exfoliative materials were precipitated in endothelial cells of PEX & PEXG eyes.