iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2021.v02i01.085Positive Clinical Impacts of Branched Chain Amino Acids Based Protein in Cachectic Hospitalized PatientsSinanAhmadBadwanMohammadSaidAlkaderYazanEmadMoumaniMaherNayef BaniEssaMuthafarMohammadSalehKing Hussein Medical Hospital, Jordanian Royal Medical Services, Amman, JordanKing Hussein Medical Hospital, King Abdullah II St 230, Amman 11733, Jordanian Royal Medical Services, JordanObjectives: Cachexia is a dysregulation of fat, protein, and carbohydrate metabolism largely due to cytokine excess; ultimately resulting in severe wasting of the body’s lean body mass (LBM), albumin, and branched-chain amino acids (BCAA) depletion. The aim of this study is to evaluate the clinical differences between two commercially available WP formulas that differ in BCAAs enrichment proportion. Methods: A retrospective analysis was conducted in our institution between Jan 2019 and Jan 2021. Patient who had 2≤ episodes of diarrhea or failed to complete one week of hospital admission were excluded. All patients’ continuous variables were analyzed using Independent Samples and One-Sample T-test while categorical data were expressed as numbers with percentages by using Chi Square test. Results: Group I (%BCAAs≥20%) demonstrated a significantly shorter length of stay (LOS) and lower overall 28-day mortality compared with Group II (%BCAAs≈12%) with Mean±SD of (9.80±1.79 days vs. 12.00±2.33 days) and Mean percentage of (20.97% vs. 13.33%), respectively. Percent changes in albumin level (%∆ALB) were significantly higher in Group I compared with Group II (35.3%±4.64% vs. 28.3%±5.49%). Conclusion: BCAAs enriched WP formula was superior to standard WP formula in stimulating ALB synthesis and LBM anabolism/catabolism ratio in cachexic hospitalized hypoalbuminemic patients.