iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2021.v02i01.016Alterations in the Serum Levels of Parathyroid Hormone, Calcium and Phosphorus in Haemodialysis Patients in Zawia Kidney Centre, Western LibyaMohamedEbsaimEttiyebLaghaRabiaA. M.YahyaRabeaaAboharbaTasnemHyediAyaAldeebKarimanAlmjdoobBackground: Chronic kidney disease (CKD) is considered the popular disorder throughout the world. It associates with abnormalities of mineral metabolism such as calcium, phosphorus and parathyroid hormone. Objectives: The study aimed to evaluate the alteration of serum levels of Ca, Ph and PTH in hemodialysis patients in in Zawia Kidney Center, Western Libya and determining the relationship of age with the levels of these parameters. Materials and Methods: One hundred subjects were included in the present study. Out of which 50 cases were dialysis patients collecting from AZ-Zawia kidney center and 50 subjects were health individuals used as control divided into male and female, mean age was 47.03±14.14 years. Five ml of venous blood was collected from each participant for estimating the serum levels of PTH, Ca and Ph. Results: The result showed that the level of PTH was higher than normal, where the mean level of PTH in dialysis patients was 421.64±391.30 and 44.59±12.32 pg/ml in the control. Ca level in dialysis patient was slightly lower than normal while Ph is nearly similar to control subjects. The level of PTH was high in young patient (580.6±440.4) and decreases with increase in age, where recorded its mean level in age group >60 year, was 240.3±321.0 and there was a significant negative correlation between age and the serum level of PTH (r= -0.3 P=0.03). However, the results showed that none significant correlation between age and the serum levels of Ca and Ph, p-value =0.461 and 0.701, respectively. In addition. the percentage of the patients who had a serum iPTH level of <150 pg/mL was 32% while that of patients with iPTH of >300 pg/mL was 46 %. Hypocalcemia and hypophosphatemia were observed in 66% and 46% of the patients, respectively. Moreover, 28%, 22% and 42% of the patients, respectively, reached the K/DOQI target range of Ca, P and iPTH. Conclusion: It can be concluded that hyperparathyroidism is a common disorder in hemodialysis patients and parathyroid hormone is decreasing whenever increase patient age. Percentage of dialysis patients, in Az-Zawia, who their serum of PTH and Ca and Ph in within target range recommending by K/DQOI was lower in comparing with non-target rang. Therefore, it is recommended that patients should consider and have attention about their health by having proper medication to adjust the level of mineral metabolism and parathyroid hormone.