iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2021.v02i01.002The Clinical Impacts of Maintenance Dextrose Saline Fluids Associated Hypercapnia in Malnourished Patients on Parenteral Nutrition SupportSuhairShaherTarawnehAsmaH. Alazab;PhObjectives: Most mechanically ventilated critically ill patients are mal-nourished and significant portion of them are taking either partial or complete total parenteral nutrition due to exogenously and endogenously multi-factors that impairs there’s enteral nutrition effectiveness. In addition to nutrition support fluids, most if not all intensive care unit admitted patients are taking dextrose saline maintenance fluids which provide approximately 0.17 Cal/ml regardless of saline concentration. This non-nutritional source of calories may have negative clinical and economic impacts if not assess adequately in mechanically ventilated patients who are also taking nutrition support. The aim of this study is to evaluate the clinical impacts of NNCs associated dextrose maintenance fluids in mechanically ventilated critically ill patients who are also taking TPN. Materials and methods: An observational retrospective study was conducted in King Hussein Medical Center Intensive Care Unit. One-Way ANOVA and Chi Square Tests were used analyzed our tested patient’s data followed by Tukey Kramer Post Hoc Test to determine the mean differences of significant dependent variables across the Eucapnic, mild hypercapnic, moderate hypercapnic and severe hypercapnic groups. Results and discussion: Our tested patients had an average age of 57.88±9.01 years in which 72.0% (85 patients) and 28.0% (33 patients) were male and female, respectively. The overall risk of dextrose saline maintenance fluids associated hypercapnia regardless of severity in our tested critically ill patients was 74.58% (88 patients) in which 27.12%, 24.58% and 22.88% of the hypercapnic patients had mild, moderate and severe hypercapnia status, respectively. Conclusion: NNCs associated dextrose saline fluids may increase the risk of hypercapnia associated ventilator weaning failure, if the NNC is not adequately assessed and subtracted from total calories inputs from enteral or parenteral nutrition support formulas.