iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2020.v01i02.032In vitro Studies on Phytochemical and Antimicrobial Activity of Afrofittonia silverstris Lindau against Some Human PathogensEreDiepreyeEbohAbrahamSiseinEtukEdikanOAfrofittonia silverstris Lindau is an important herb that is widespread in Africa. The leaves are used in various decoctions traditionally to treat diseases most especially microbial infections. In this study, the phytochemicals of the plant were screened and their quantities determined. Chromatographic studies were also carried out. The antimicrobial activities of the plant were also evaluated. Alkaloids, tannins, flavonoids, cardiac glycosides, phenolics and saponins were found to be present as phytochemicals. In the antimicrobial activity testing, the cup-plate diffusion method was used and the result showed that the ethanol extract inhibited the growth bacillus species, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus. However, dichloromethane extract showed very less antimicrobial activity on the other test organisms such as Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus.