iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2020.v01i01.035The Clinical Impacts of Either Peripheral or Central Lipofundin Mct/Lct-Amino Acid Co-Infusion Versus Central Amino Acid/Intermittent Lipofundin Mct/Lct in Severe Mal-Nourished PatientsSamerMohammadAlefeishatMalekAbedALoudatWafa'IssaAlomoushMohammadBassamJalailehTareqMohammadAljbouri“Moh’dNour” Mahmoud BaniYounesJaafarAbd Alrahman AbuAbeeleh;ReemAbdelRObjectives: Nutrition support is critically important in management malnourished hospitalized patients who are intolerated to Enteral Feeding (EF) regard Less the offending inciting factor. In this case situation, total or Partial Parenteral Nutrition (TPN) may save malnourished patient’s life. Regarding TPN, the route may be either Peripheral (PPN) or Central (CPN). Intravenous Lipid Emulsions (ILEs) is a major component of TPN due to its unique dual nutritional advantages in providing high dense calories and essential fat acids of Ꞷ-3 and Ꞷ-6. The aim of this study is to compare the clinical impacts of using ILE co-infusion with Amino Acid (AA) in daily pattern, either centrally or peripherally, (Group I) with intermittent ILE co-infusion with AA centrally (Group II). Methods: We performed a retrospective analysis of patients who were in tolerated to EF and were candidate to either peripheral or central TPN. Patients were excluded if they discharged or died before completing at least 1 week of TPN. All patient’s continuous variables were expressed as mean± SD by using the Independent Samples T-Test while categorical variables were expressed as numbers with percentages by using Chi Square Test. Results: The mean overall age was 58.37±9.95 years and 224 (68.7%) patients were male. The changes in albumin level (∆ALB) was significantly higher in Group I than Group II (1.49±0.89 g/dL vs 0.71±0.78 g/dL, respectively). The hospital Length of Stay (LOS) and overall 28-day hospital mortality were significantly lower in Group I compared with Group II (14.05±1.71 days and 19.51% vs 16.01±2.57 days and 32.09%, respectively). Conclusion: In summary, IFE is an integral part of TPN and has a significant positive clinical impact especially, if it is administered in daily manner regardLess the route.