iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2020.v01i01.014Anticataract effect of kolaviron on porcine lenses in experimental cataract modelDaminolaA.U.FandEbohA.SModern herbal medicine has played a significant role in treating oxidative stress and related complications. Kolaviron was evaluated for possible anticataractogenic potential. Following incubation of porcine lenses for 24 h at 37 0C. Porcine lenses 160 randomly distributed into control containing no selenite 40 lenses. Toxic control containing selenite, kolaviron and selenite group and finally Gallic acid and selenite group were obtained from a local slaughterhouse and homogenized in 50 mM Tris-HCl, pH 8.0, containing 0.1 M NaCl, 5 mM EDTA, 0.01% β-mercaptoethanol and 0.02% sodium azide. The mean activities of catalase, superoxide dismutase and Glutathione-S-transferase and the mean level of reduced glutathione were all significantly (p<0.05) higher in Group III lenses than the mean values in Group II lenses. The mean concentration of malondialdehyde in Group III lenses was significantly (p<0.05) lower than that in Group II lenses. Porcine lenses simultaneously exposed to selenite and kolaviron showed increased mean activities of enzymatic antioxidants, mean levels of reduced glutathione and decreased malondialdehyde levels. Further studies are required to confirm whether the kolaviron can be developed for pharmacological management of cataract.