iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2020.v01i01.011The Clinical Impacts of Immuno-Enhancing Nutrients-5 Novel Combination for Covid-19 Infection"Moh'dNour" Mahmoud BaniYounesMohammedAliObeidatJaafarAbd Alrahman AbuAbeelehBackground: As COVID-19 has become the recent major concern all over the world; as this virus was able to paralyze most of the human beings’ activities, an urgent solution to eradicate and control the spread of this disease is needed. It is known that both Ferritin: Albumin and Monocyte: Lymphocyte ratios are increased in COVID-19 infection. In our study, we primarily investigated the dynamic effects of Hydroxychloroquine+Azithromycin+High dose Vit C or immuno-enhancing nutrients (IENs) on this innovated combined ratio across six studied groups. Methods: This was a single-center randomized, controlled, open label study was conducted on 48 eligible patients in the COVID-19 isolation department at Queen Alia Military Hospital, Royal Medical Services, Amman/Jordan over 7 weeks. Age≥16 years and positive RT-PCR are considered the major inclusion criteria. An ANOVA+Tukey Kramer post-hoc multiple comparison and Chi square analyses were primarily used in this study. Result: Our total study population was 48, 79.2% were males and 20.8% were females. The age of the total sample was 31.35+14.67 years. The hospital length of stay, variation in body temperature, up-trending in R:rR was significantly lowest in groups that include IENs followed by high dose Vitamin C than groups without them. There is insignificant role of antibiotic in mild cases of COVID-19 infected patients with pulmonary infiltration. Conclusion: The existing approved COVID-19 drugs of Hydroxychloroquine with or without Azithromycin are likely ineffective without our immune system support and the IENs likely improve the clinical outcomes at least dynamically in the worst scenario.