iarjmsIARJMSIARJMS2708-3594https://doi.org/10.47310/iarjms.2020.v01i01.008Alteration of Lecithin: cholesterol acyl-transferase activity correlates with estimated glomerular filtration rate in adult Sickle cell disease patientsMathiasAEmokpaeBackground: Glomerular filtration rate is an important clinical indicator of kidney function, Sickle cell disease (SCD) is regarded as a chronic vasculopathy marked by endothelial injury and lipoprotein metabolism may be affected. Objective: To correlate the activities of lecithin:cholesterol acyl-transferase (LCAT) and lipoprotein lipase (LPL)  in adult SCD patients with  estimated glomerular filtration rate (eGFR). Methods: One hundred and eighty confirmed SCD patients were consecutively recruited for the study. They consisted of 120 males aged: 26.4±2.4 years and 60 females aged 25.4±1.6 years. They were grouped into 3 categories based on their eGFR viz: eGFR >90mL/min/1.73m2; eGFR 60 to 89mL/min/1.73m2 and eGFR <60mL/min/1.73m2. Serum triglyceride and total cholesterol were determined using reagent kits by Randox laboratories, UK, while HDL- cholesterol was determined in the supernatant after precipitation with magnesium chloride/ phosphotungstic acid solution. LCAT was measured using the Anasolv LCAT assay kit supplied by DAICCHI chemicals, Japan and LPL was assayed by colorimetric method as previously described. Results: Serum LPL and LCAT were significantly lower (p<0.001) with decreasing eGFR. The eGFR correlated negatively with urea (r = -0.174, p<0.02), creatinine (r = -0.195, p<0.01) and triglyceride (r = -0.145, p<0.05) while HDL-c (r = 0.149, p<0.05), LPL (r = 0.148, p<0.05) and LCAT (r = 0.209, p<0.005) correlated positively with eGFR. Conclusions: The activities of LCAT and LPL were lower with decreasing levels of glomerular filtration rate. The importance of adequate lipid and lipoproteins metabolism cannot be overemphasized in the management of SCD patients.