iarjalsIARJALSIARJALS2708-5104https://doi.org/10.47310/iarjals.2023.v04i01.013Study The Effect of Vitamin E-Selenium Compound On TSH And Weight In Local Goat's BreedsMaysaaM. A.Al-RsitmawiHyderKareemAbboodIhabAbdullahSaeedThe study was carried out to investigate the effect of vitamin E-selenium on the prevention of endemic goiter in the local goat herd and regulate the estrous cycles. Serum TSH (thyroid stimulating hormone) levels were measured as an index of thyroid gland activity and their impact on the productive performance (weight) of local female goats. A total of 15 female goats aged 2-3 years and weighing 28-35 kg were randomly assigned to the productive season (during the first gestation period of 1-3 months), divided into three groups of five goats each. The negative control group (G1) received distilled water alone, the second group received 5 ml of E-Se solution, and the third group received 10 ml Se-E solution. For two weeks, the medication was administered through intramuscular injection. Weights were assessed before and after the experiment using a ground scale, and blood samples were obtained from all animals after two weeks of therapy to determine thyroid stimulating hormone (TSH) levels in the blood. For G2 and G3 animals TSH level means revealed statistically significant differences (P<0.05), while G3 animals significantly outperformed (P<0.05) where TSH level mean was 0.077±0.05 mlU/ ml compared with G1, and significant increases (P<0.05) in mean of body weights of G2 animals 33.6000±0.8055 kg compared with G3 and G1. This indicates to the effect of vitamin E and selenium in increasing TSH levels and controlling thyroid gland growth and activity by increasing the number of follicles and ability to store iodine. Because it dramatically increases the activity of enzymes that rely on selenium, it enhances goat health and herd productivity while reducing the incidence of abortion.