srjcmsSRJCMSSRJCMS2788-8851https://doi.org/10.47310/srjcms.2024.v04i01.003Odontogenic Keratocyst: A Comprehensive ReviewAnjaliThakurNadeemsharvanOdontogenic Keratocysts (OKCs), previously classified as Keratocystic Odontogenic Tumors (KCOTs), are a fascinating and challenging subset of developmental odontogenic cysts, renowned for their distinctive clinical characteristics and notably high rates of recurrence. This comprehensive review endeavors to elucidate the multifaceted nature of OKCs, providing an in-depth exploration across several key dimensions. It encompasses a detailed examination of their clinical presentation, which often ranges from asymptomatic cases to more aggressive manifestations and delves into the unique histopathological features that set OKCs apart from other odontogenic cysts. The review also sheds light on the etiology and pathogenesis of OKCs, with a particular focus on the recent revelations regarding their genetic underpinnings and the implications thereof. Critical insights into the methodologies employed in the diagnosis of OKCs are presented, highlighting the importance of accuracy in differentiating them from other similar lesions. Furthermore, the review discusses the spectrum of treatment modalities available, from conservative approaches to more radical interventions and underscores the significance of emerging adjuvant therapies in reducing recurrence. Finally, it addresses the recent advancements and ongoing debates within the field, illustrating the dynamic and evolving landscape of OKC management and its implications for patient care and outcomes.