iarjpIARJPIARJP2709-9512https://doi.org/10.47310/iarjp.2023.v04i02.015Hepatoprotective Effect of Emoxypine Succinate Against CCL4 Induced liver injury in Experimental Rats ModelAymenA.BashThe liver is the most important organ that considered as target for chemical induced injury. The free radical concept of liver damage reveals new possibilities for the use of medicines in the treatment of such cases. The present study aimed to evaluate the hepatoprotective effect of emoxypine succinate in experimental model of rats with hepatitis with toxic genesis induced by administration of carbon tetrachloride. Forty mature male wistar rats were randomly divided into three group. The animals in the control group (n = 10) did not receive any medication and the second group animals (n =15) received single intravascular (I.V.) injection of carbon tetrachloride (CCL4) (at a dose of 10 mg/kg). Moreover, the third group (n =15) was given the emoxypine succinate at a dose of 25mg/kg twice dialy for 30 days in addition CCL4. After 30 days, CCL4 prompted signified hepatic injury indicated by lower reactivity and elevated biochemical parameters, such as aspartate aminotransferase, alanine aminotransferase and aldehyde dehydrogenase, compared to the control and the third group. However, the group that received CCL4 and emoxypine succinate had significantly lower hepatic dysfunctions, compared to the second group. Remarkably, emoxypine succinate supplementation reduced the apoptotic cell death and harmful oxidative damage caused by CCL4. The antioxidants and free radical scavenger activity of emoxypine succinate were thought to be responsible for its protective benefits.