iarjimphIARJIMPHIARJIMPH2709-331Xhttps://doi.org/10.47310/iarjimph.2022.v03i02.022Evaluation of Histo-Pathological Finding and Tumor Burden among Prostate Cancer Patients at Tertiary Care HospitalViperSharma Dr. SunilKumarRishabhChadhaBackground: The present study was done to evaluate the histo-pathological finding and tumor burden among prostate cancer patients. Material and Methods: Forty-four patients with suspected PCa on clinical assessment and/or raised serum PSA levels (>4ng/ml) were prospectively recruited. Patient who underwent prostatic biopsy prior to 68Ga-PSMA PET/CT and mpMRI, deranged renal function tests or coagulogram and refused consent were excluded. Forty-four patients underwent 68Ga-PSMA PET/CT and 33 patients underwent mpMRI and biopsy. Results: Mean age of patients was 66.61±9.3 years and median PSA level was 13.4 ng/ml (IQR 13.9). Malignancy was detected in 16/33 (48.5%) patients who underwent biopsy. Tumors were low grade PCa in 9 cases and high grade PCa in 7 cases. Prostatitis was detected in 4 cases. [Granulomatous prostatitis (n=1), Acute/chronic prostatitis (n=3)]. In all 16 patients diagnosed of having malignancy on biopsy, adenocarcinoma was detected in all on histopathology. Prostatic intra-epithelial neoplasia (PIN) was not detected in any case. The range of tumour burden in patients was from <5 to 70%. One patient with tumour burden of less than 5% was found to be negative on 68Ga PSMA PET/CT. Conclusions: The present study concluded that all the cases of Prostate Cancer were having adenocarcinoma and had high tumor burden. Histopathological examination of prostatic specimens has important role in the diagnosis and management of various prostatic lesions.