iarjimphIARJIMPHIARJIMPH2709-331Xhttps://doi.org/10.47310/iarjimph.2022.v03i02.020Is Nipple Discharge so Serious?MayAbdulSalamJawadK.Al-DiwanBackground: Nipple discharge is an important complaint that frequently results patients’ anxiety and physician concern. It accounts 5% of all breast related symptoms. The evaluation and management of patients with nipple discharge aims to identify malignant cases from those associated with benign disease. Objectives: Studies on the nipple discharge are scare among women; therefore, the study was carried. Patients and Methods: Between July 2021 and December 2021, 100 patients with nipple discharge were included in the study. All patients were interviewed and clinical assessment based on a careful history, physical examination, imaging studies and cytological examination. Results: The age of all patients with nipple discharge was 39.9 years, ranging from 16 to72 years. BI-RADS >2 was noticed among 6(13%) of those with inflammatory lesion, 4(8.7%) of those with benign lesion and 11(23.9%) of those with malignant lesions. BI-RADS >2 was significant prominent in malignancy (p = 0.01). It was non-significantly present among inflammation and benign (p = 0.3 and 0.1, respectively). Color of discharge was bloody 5(26.3%) and serous 5(26.3%) in malignant lesions, respectively. It was bloody 5(13.9%) and serous 2(5.3%) of the benign lesions. In inflammatory lesion, the discharge was blood 2(10.5%), serous 4(10.5%) and purulent 3(15.8%). Bloody discharge was significantly prominent in benign and malignant lesions (p = 0.02 and 0.03, respectively). Conclusions: High BI-RADS are related to malignancy, bloody and serious nipple discharge related to malignancy.