iarjimphIARJIMPHIARJIMPH2709-331Xhttps://doi.org/10.47310/iarjimph.2021.v02i02.039Spectrum of Malignancies Reported At a Tertiary Care Hospital and Its Comparison with Other Cancer Registries in IndiaKusumJashnaniRoshniPatilAmitBhondveBackground: According to Report of National Cancer Registry Programme, 2020 India’s cancer burden during 2020 was 1.39 million. The crude mortality rate varied from as low as 9.7 deaths per 100,000 males to as high as 115.0 per 100,000 males. Among females, it ranged from 6.8 deaths per 100,000 females in Nagaland PBCR to 69.6 per 100,000 females. There are also differences of incidences in HBCR/PBCR and Tertiary Hospitals. The overall aims and objectives are to provide incidence data that is comparable among the cancer registries reported in Mumbai, as well as with cancer registries in other urban cities of India. Results: Breast constituted the most common site (25.0%) followed by cervix (16.4%), mouth (5.3%), thyroid (4.4%), stomach (3.8%), colon (3.7%), ovary (3.3%), gallbladder (3.3%), oesophagus (3.3%), uterus (2.8%) as the top ten common sites of malignancies in females. Mouth (9.0 %), urinary bladder (6.6%), prostate (5.1%), gallbladder (5.0%), stomach (4.9%), tongue (4.8%), oesophagus (4.7%), larynx (4.6%), NHL (4.2%), lung (4.0%) were the top ten common sites of malignancies in males. System wise distribution of cases revealed that genitourinary cancers were most common (20.8%), followed by gastrointestinal tract cancers (17.40%) and breast cancer as the 3rd most common group (12.2%). Conclusion: Present study puts forward the idea of distribution of various cancers reported in this region where institute like TMH is juxtaposed. Emphasis to be given on compilation of figures from HBCRs, PBCRs and tertiary care medical institute pathology department data to obtain comprehensive national database.