iarjimphIARJIMPHIARJIMPH2709-331Xhttps://doi.org/10.47310/iarjimph.2021.v02i02.037Van Wyk-Grumbach Syndrome: The Importance of Early Diagnosis and ManagementWasnaaHadiAbdullahNabeehaNajateeAkramVan Wyk-Grumbach syndrome (VWGS) is one of the most perplexing pediatric syndromes, which is a rare kind of sexual precocity linked to hypothyroidism in children. This condition represents an aberration from the usual norm that a delayed growth pattern is associated with delayed puberty, which is followed by the majority of children with long-lasting hypothyroid. Early diagnosis and establishment of replacement therapy with thyroxine can alleviate the already developed symptoms and avoid patients being exposed to unnecessary surgical interventions .we reviewed studies and case reports recently published on this subject in which patient with this syndrome have different presentations and discussed the benefit of early establishment of thyroxine therapy in reversing the clinical and laboratory changes.This paper critically discussed the importance of being aware of this syndrome to avoid subjecting the patients to unnecessary laboratory tests and/or surgical interventions.