iarjimphIARJIMPHIARJIMPH2709-331Xhttps://doi.org/10.47310/iarjimph.2021.v02i02.023Nisome: As a Nano Carrier in Drug Delivery System: A ReviewPujaMarutiBangarNiosome was introduced in 1978 by Lansone [1]. Niosome is a nonionic surfactants based on vesicle. They are formed mostly by nonionic surfactants and cholesterol incorporation as an excipient [2]. Niosome can be used as carrier of amphiphilic and lipophilic drug [3]. The niosome have ability to encapsulate different type of drug within their multi environmental structure. They present a structure similar to liposome and hence they represent alternative vesicular system with respect to liposome [4].The main aim of development of niosome is to control the release of drug in a sustained way, modification of distribution profile of drug and for targeting the drug to specific body site [1].There are different types of niosome multi lamellar vesicle (MLV), Large unilamellar vesicle (LUV) and Small unilamellar vesicle (SUV). There are many method of preparation of niosome such as Hand shaking, ether injection, bubbled method, ethanol injection and multiple membrane method. Generally the approach of niosome by various routes has reported. They are oral, parenteral, pulmonary, transdermal, vaginal and nasal routes. This review article represent the structure of niosome, advantages, disadvantages, method of preparation and characterization and factor affecting on formulation of niosome, zqapplication and types of niosome.