iajabmsIAJABMSIAJABMS2709-3298https://doi.org/10.47310/iajabms.2021.v02i02.007Coagulation Profile and Inflammatory Markers among Chronic Spontaneous Urticaria Patients in Tertiary Care HospitalShailjaChauhanVikantVermaBackground: In chronic urticaria, activation of coagulation cascade occurs that corresponds to the severity of disease.However its etiopathogenesis still remains unknown. Therefore present study was done to evaluate the variation in coagulation profile and other inflammatory markers among patients with Chronic Spontaneous Urticaria. Methods: All 100 consecutive patients of chronic urticaria aged 18 years and above attending the outpatient Dermatology, Venereology and Leprosy clinic of Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh between April 2016 and March 2017. Information on age, gender, symptom duration, previous medical history etc. was collected. Results: The study comprised 100 consecutive patients with chronic Spontaneousurticaria and had 25 males and 75 females (M:F = 1:3) aged between 18 and 69 (Mean±SD = 36.12±10.88) years. The mean prothrombin time (PT), activated partial thromboplastin time (aPTT), international normalized ratio (INR), thrombin time (TT) and Absolute Eosinophilscount were 14.99±2.9, 33.1±5.2, 1.08± 0.3, 17.01 ±0.798 and 205.9±142.3 respectively. Twenty three patients had elevated plasma D-dimer levels of ≥0.3 mg/L whereas 77 had normal levels (≤0.2 mg/l). Only 3 patients had  Serum C-reactive protein>3.0 mg/L while 97 patients had Normal value  below 3.0 mg/L. 69 patients had  Prothrombin Time(PT)>13.7 seconds while 31 patients had Normal value between  11.4-13.7 Seconds. 6 patients had Activated partial thromboplastin time (aPTT)>41.8seconds while 94 patients had Normal value between 27.8-41.8 Seconds. 3 patients had Thrombin time (TT)> 18seconds while 97 patients had Normal value between 15-18 Seconds. 8 patients had International normalized ratio (INR)> 1.4while 92 patients had Normal value of <1.4.  Four patients had Absolute eosnionphil count>500 cells/mm3while 96 patients had Normal value between 20-500 cells/mm3.Conclusions: Our results might support the possible involvement of both coagulation and fibrinolysis pathway in the urticariapathomechanism. Further prospective studies in larger populations conducted at multiple centres are required to expand further our findings.