iajabmsIAJABMSIAJABMS2709-3298https://doi.org/10.47310/iajabms.2021.v02i01.019Assessment of, N-Terminal B-Type Natriuretic Peptide, and Cystatin-C of Serum Levels in Patients with Heart FailureChasiblatifAliAhmadabd alraheem IbrahemDahyAnwarM.RasheedBackground: Heart failure timely and effective diagnosis and treatment directly affects the prognosis of patients, so early diagnosis of heart failure treatment is very important. The current diagnosis of heart failure has yet to be further improved. To investigate the relationship between plasma levels of cystatin-C and NT-proBNP in cardiac structure and function in patients with heart failure (HF) and the early detection of failure. Methods: Patients were recruited from the coronary care unit (CCU) of Al-Yarmouk Teaching Hospital and were admitted and verified as cases of HF by specialist cardiologists. Between the 1st of November 2017 and the 1st of April 2018; 48 patients (29 males and 19 females), were diagnosed to have HF and were included in the study. The total number of HF patients admitted to the CCU of the hospital during the study period was 100 patients but 52 patients were ruled out according to the exclusion criteria of the study such as Acute Myocardial Infarction, active myocarditis, Drug abuse or an alcohol drinker, renal failure .Apparently healthy subjects were recruited from the staff of Al-Mustansiryah Medicine College. They comprised (40) subjects (30 males and 10 females). Each subject who was recruited in the control group has underwent a full history and physical examination with a recording of : age, gender, smoking, chronic diseases and medications. Any subject in control group must be fasting for 8-14 hours at the time of drawing of blood specimen. Consent was taken from all subjects in the control group after being told about the aim of the study. The plasma Galectin-3 and cystatin-C and NT-proBNP levels were compared between the two groups to observe the value of plasma Galectin-3 and cystatin-C combined with NT-proBNP in the diagnosis of heart failure. Results: the levels of plasma cystatin-C and NT-proBNP were significantly higher in patients with heart failure Compared with the healthy control group. The levels of plasma cystatin-C and NT-proBNP increased significantly (p<0.01). The area under the ROC curve for the combined detection of plasma cystatin-C and NT-proBNP was greater than the area under the NT-proBNP alone tests. Conclusion: The combined detection of cystatin-C and NT-proBNP has high sensitivity and specificity in the diagnosis of heart failure and can be used as a new detection mode.