iajabmsIAJABMSIAJABMS2709-3298https://doi.org/10.47310/iajabms.2021.v02i01.007Influences of Aqueous Leaves Extracts of Massularia Acuminata on Heamatology and Hepatotocytes Parameters/Biomarkers in Aluminium Chloride-Treated Wistar RatsBAKAREO.SThe study investigates the effects and potency of administration of aqueous leaves extract of Massularia acuminata and of sildenafil citrate on liver and kidney function parameters in aluminum chloride-treated in male albino rats. Thirty-five male rats were completely randomized into 7 groups of 5 animals each. Rats in group A is the control and were administered with distilled water, those in group B were treated with aluminum chloride which served as a toxicant, those in group C and D were treated respectively with sildenafil citrate alone; and toxicant and sildenafil citrate; while those in groups E, F, and G were treated with various doses of the extract: 100, 300, and 500 mg/kg body weight of Massularia accuminata (Extract) respectively as an intervention against the aluminium chloride toxicities. At the end of the study, the kidney and liver were harvested and homogenized and both the homogenized sample and blood samples were taken for biochemical assays. It was observed from the results that, there was a significant statistical increase in the activity of ALT and AST (serum, kidney and liver) in aluminum treated group perhaps due to the ROS and toxicities generated to the organs by induced toxicant (aluminium chloride) whereas there was a noticeable decrease level of these enzymes in control group. Also, it was observed that there was a significant decrease in the activity of ALT and AST (Serum and kidney) in the group administered with extract of Massularia acuminata at 100 mg/kg and 300 mg/kg body weight respectively causes no damage to the tissue analyzed, however other group administered with extract (500mg/kg body weight) were significantly elevated. It was observed that, there was a significant decrease in the activity of ALP in the negative control group compared to the control group which is due to the induced toxicant (aluminium chloride). It was observed that there was a significant decrease in the activity of ALP in the animals administered with 100mg/kg body weight and 300mg/kg body weight of plant extract below the control group. It was also observed that there was no significant difference in the group administered 500mg/kg body weight of plant. It was observed that, there was a significant decrease in the activity of AST in the negative control group compared to the control group which is due to the induced toxicant (aluminium chloride). It was also observed that there was a significant decrease in the activity of AST and AST in the group administered different doses of Massularia acuminata when compared to sildenafil citrate, and sildenafil plus aluminum chloride groups. The haematology results show an increase or elevated level in erythrocytes (RBC), mean corpuscular haemaglobin concentration (MCV), Neutrophil, MCH leukocytes (WBC) and platetcrit (PCT) in the extract-treated groups and sildenafil-treated as does in the control groups. The histology results revealed that extracts of Massularia acuminata may restored the architecture of the liver membrane when compared with the toxicant groups. The result of the histology of the photomicrograph of the liver revealed a normal of the hepatocyte is observed across all the groups with clear central veins, which indicates that the extract of Massularia acuminata preserves the normal architecture of the hepatocytes and thus the cell functions. In conclusion, from the results obtained above, it could be inferred that the aqueous leave extracts of Massularia acuminata possess a great potential of ameliorating and restoring hepatocyte damage induced by toxic chemicals and the potency of the extract, also may also find a great influence in boasting the immune system and hematological parameters in the animals, which are the keys to survival of the cell to normal body physiological functions.