iarmsIARMSIARMS2709-3255https://doi.org/10.47310/iarms.2021.v02i02.010Reformative Effect of Jyotishmati (C. Paniculatus) In Chemical Induced Hepatotoxicity in Experimental AnimalsChaudhariPratikShantaramRanjeetSinghBargodeSourabhJainKarunakarShuklaThe present study was performed to evaluate the ameliorative effect of celastrus paniculatus against CCl4 induced hepatotoxicity in rats. In the present study, Celastrus paniculatus was selected for hepatoprotective activity owing to its traditional use. The liver function is assessed by determining the activities of SGOT, SGPT, SALP, i.e. enzymes present in the cytoplasm. In case of hepatotoxicity, the enzymes move into the bloodstream and their amount confirms the liver damage extent. The plant material was extracted by continuous hot percolation Soxhlation and the percentage yield calculated by the following formula was found to be 2.41 % (by ethanol). Phytochemical screening of ehanolic extract of Celastrus paniculatus showed the presence of carbohydrate, alkaloid, protein, flavonoids, tannin and phenolic compound, saponin, triterpenoids and steroids and absence of glycoside. In case of acute oral toxicity study when animals were treated with 5, 50, 300 and 2000 mg/kg b.w. of dose for 72 hours there was no mortality and any behavioural changes, so the dose will be choosen as 200 mg/kg b.w. on the basis of LD50. Administration of ethanolic extract showed a substantial decrease in SGPT, SGOT, SALP level (p <0.05) at a dose of 200mg/kg. Similarly, treatment with hepatoprotective drug such as silymarin showed a significant decrease in SGPT, SGOT and SALP levels. Therefore, it was reported that Celastrus paniculatus extract treatment normalize few morphological features of the liver in rats with CCl4- induced hepatotoxicity.